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Nitric Oxide Research


The 1998 Nobel Prize went to three American scientists for discovering the tie between nitric oxide (NO) and cardiovascular health. The following studies confirm the need to boost NO production in your body.


Dr. Rainer Bӧger explains the amazing cardiovascular benefits of nitric oxide

Nitric oxide (NO) is one of the smallest molecules in the human body, but like oxygen (O2), it plays an extraordinarily important role for maintaining a healthy life. Nitric oxide keeps arteries wide, so that oxygen can be easily delivered to all the organs where it is needed.

NO is produced, in many different cell types throughout the body, from the amino acid precursor, L-arginine. The conversion of L-arginine to NO makes it a very unique amino acid that is of essential nutritional importance.

The site of NO production determines its biological effects:
In the arteries, NO keeps blood flow high and protects blood from clotting, it lowers blood pressure and keeps arteries smooth and flexible.
In the gut, NO enhances intestinal function and prevents obstipation.
In the airway system, NO helps keep air flowing freely to the lungs and prevents bronchial inflammation.
In the brain and nervous system, NO decreases pain sensation and contributes to good memory formation.

By enhancing NO production, L-arginine is able to promote all of these effects. Thus, it is no wonder that such a huge diversity of organ functions are positively affected by L-arginine supplementation. Some people may call it a wonder, but I call it the science behind L-arginine.

Indeed, people with all different kinds of ailments, from high blood pressure to loss of memory, from physical exhaustion to flares of inflammatory diseases, have reported improvements in their health status while on regular L-arginine supplementation.

One true fact needs to be considered, though, when one contemplates about this broad variety of health benefits: None of them can be achieved if L-arginine levels in blood are not successfully elevated above .

The success of an L-arginine supplement can also be explained by additional ingredients that support the stimulation of NO:
Resveratrol, the powerful antioxidant contained in red wine, supports the biological actions of NO on cells by reducing toxic oxygen radicals that may not only destroy the NO molecule, but also cause severe harm to the cell itself.
Vitamin D3 has been known as a vitamin that is good for bone health; however, medical research in the last few years has revealed that it is also an important regulator of glucose and fat metabolism
Thus, the power of a supplement rests in the quality and science coming with its ingredients.

Age-associated changes in nitric oxide metabolites nitrite and nitrate

Int J Clin Lab Res. 2000. 30:83-85.
M. Toprakçı, D. Özmen, I. Mutaf, N. Turgan, Z. Parıldar, S. Habif, İ. Güner and O. Bayındır

Nitric oxide is essential in staving off cardiovascular risk factors such as aging, hypertension, and atherosclerosis. The aim of this study was to determine whether increased age resulted in decreased serum nitrite and nitrate levels—the end-products of nitric oxide—in healthy subjects. Healthy individuals were divided into five age groups and their serum nitrite and nitrate levels were measured. Analysis showed that nitrite levels were not significantly different, but nitrate concentrations exhibited significant differences. This suggests that nitric oxide synthesis is reduced with age, decreasing the vasodilation essential to vascular health.


Nitric oxide—from mediator to medicines

J R Coll Physicians Lond. 1994 May-Jun;28(3):209-19.
Vallance P, Moncada S.

Nitric oxide is involved in a wide range of physiological processes in humans and animals. It controls vascular tone, acts as a neurotransmitter and neuromodulator in the central and peripheral nervous systems, and influences the activity of the immune system. Substances that selectively enhance or inhibit its synthesis or removal and modify its effects are likely to yield interesting therapeutic agents.


Nitric oxide: an antioxidant and neuroprotector

Annals of the New York Academy of Sciences. Volume 962. p 389. May 2002.
Kochupurackal P. Mohanakumar, Bobby Thomas, Sudarshana M. Sharma, Dhanasekharan Muralikrishnan, Rukhsana Chowdhury, Chuang C. Chiueh

Evidence suggests that nitric oxide acts as a powerful antioxidant, protecting cells against neurotoxicity and other dangers. In vitro and in vivo laboratory results are reviewed to find the effects of nitric oxide on MPTP neurotoxicity and see what other protections nitric oxide may offer.


The discovery of nitric oxide as the endogenous nitrovasodilator

Hypertension. 1988 Oct;12(4):365-72.
Moncada S, Palmer RM, Higgs EA

Nitric oxide is indentified as the key factor in relaxing arterial walls and keeping platelets operating at optimum levels and functionality. Research also indicates that L-arginine is the precursor for the synthesis of nitric oxide.


Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: The changes with aging

The Prostate. Volume 48, Issue 1, pages 40–46, 15 June 2001. DOI: 10.1002/pros.1079
Ken Aikawa, Takashi Yokota, Hiro-oki Okamura, Osamu Yamaguchi

Nitric oxide plays the key role in the non-adrenergic non-cholinergic nerve-mediated relaxation of the prostate. This study evaluates whether nitrinergic innervation of the prostate is reduced with aging, and whether a reduction of this innervation alters the relaxant properties of prostatic tissue. Researchers found that both nitric oxide-mediated relaxation and nitrinergic innervation are reduced with aging in this animal model, confirming the body’s need for help in producing nitric oxide later in life.